Structure of PDB 7ak1 Chain A

Receptor sequence
>7ak1A (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
PLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLT
EYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSE
NCLCVQNILKLMQEKETGLNVFLLDMCRKTANIVFGYATCANGIFMKFLK
DRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQG
TEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYT
SIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKH
CLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLD
M
3D structure
PDB7ak1 Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
ChainA
Resolution2.507 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RJH A V344 K379 V381 L383 E390 N393 A394 E397 L401 W580 A583 Q676 L715 M717 V7 K42 V44 L46 E53 N56 A57 E60 L64 W214 A217 Q310 L349 M351
BS02 MG A R392 L440 C441 R55 L103 C104
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7ak1, PDBe:7ak1, PDBj:7ak1
PDBsum7ak1
PubMed33252239
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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