Structure of PDB 7ai6 Chain A

Receptor sequence

>7ai6A (length=788) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

SAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLL
DISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAIAEQIGDPAT
SKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDIS
SGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPL
WEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLSAAGALLQYAKCTQRTT
LPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDSTVTP
MGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERI
LARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFA
ELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLE
VRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERY
IIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAE
LDVLVNLAERAYTLNYTSPTFIDKPGIRITEGRHPVVEQVLNEPFIANPL
NLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPID
RIFTRVGFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWAVA
ENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSV
QDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS

3D structure

PDB

7ai6 The selection process of licensing a DNA mismatch for repair.

Chain

Resolution

6.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	T11 P12 M13 M33 G34 D35 F36 Q95 P99 V106 R108	T10 P11 M12 M32 G33 D34 F35 Q94 P98 V105 R107
BS02	dna	A	F36 E38 I53 S54 T56 R58 G70 P72 H74 L495 K496 R500	F35 E37 I52 S53 T55 R57 G69 P71 H73 L494 K495 R499
BS03	ADP	A	F596 I597 N616 M617 G618 G619 K620 S621 T622 H760	F595 I596 N615 M616 G617 G618 K619 S620 T621 H748

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008301	DNA binding, bending
GO:0016887	ATP hydrolysis activity
GO:0030983	mismatched DNA binding
GO:0032136	adenine/cytosine mispair binding
GO:0042802	identical protein binding
GO:0043531	ADP binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0000018	regulation of DNA recombination
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006974	DNA damage response

	Cellular Component
GO:0005829	cytosol
GO:0032300	mismatch repair complex
GO:1990710	MutS complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7ai6, PDBe:7ai6, PDBj:7ai6
PDBsum	7ai6
PubMed	33820992
UniProt	P23909\|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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