Structure of PDB 7agj Chain A

Receptor sequence
>7agjA (length=731) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
TMYVIKRSGRKEKLDINKIRIAIKFACEGLNVDPLELEADAQIQFRDGIT
TKEIQQLLIKTAAEKVSAERPDWTYTAARLLLYDLYKDVAHLRGYSLRDD
LGKYKPYNRKNFYSFVKEYVEKGIYGEYLLENYSEEDFNKLANYIKPERD
LYFTYTGIKILYDRYLVRDEEGRVIELPQEMYMLIAMTLAVPEKPEERLK
WAKKFYDVLSEHKVTVATPTLMNARRPFTQLSSCFVLTVDDDLFDIFDNV
KKAGMISKFAGGLGVYLGKIRATSGVIPVVKLINDTMTYVSASITLDIWH
KDILDFLEVKTERKKAHDIHPAVSIPDLFMKRLKNREDWTLIDPYWARQY
ITRKIEPKGLEDFYGEEFEKWYLELEENLPSYAKKKVNSFELWKRLLTVA
FETGEPYIFFRDEANRKNPNKHTGMVYSSNLCHEIVQTMSPSKHEKPVLD
PETGEITYKKEAGDLPVCNLGSVNLGKVHTEEEIKEVLPLLVRMLDNVIE
MNFYAIPEAEYTNKRYRAIGIGVSNYHYCLVKNGIKWESEEHLKFADKLF
ELIAFYALKGSLELAKERGRYKLFDGSNWSKGILFGRSVEEIEENSRQNG
NNLPWRELAEEIKKYGIRNAYLLALMPTGSTSLILGATPSIDPIFARFYK
EENILPQVPPEVDRFYWHYKTAYTIDHEWTIRAAAVRQKWIDQAQSLNLF
VDPQNIDGPRLSRLYELAWELGLKTIYYLRS
3D structure
PDB7agj Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V5 K7 R8 E13 D16 K19 I20 T52 Q56 K88 V4 K6 R7 E12 D15 K18 I19 T51 Q55 K87
BS02 ATP A K19 F26 Y84 K88 Y105 K18 F25 Y83 K87 Y104
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7agj, PDBe:7agj, PDBj:7agj
PDBsum7agj
PubMed34941255
UniProtO66503|RIR1_AQUAE Ribonucleoside-diphosphate reductase subunit alpha (Gene Name=nrdA)

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