Structure of PDB 7adv Chain A

Receptor sequence

>7advA (length=367) Species: 11963 (Human spumaretrovirus)

DAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIV
LQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKA
SGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPT
KAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEF
STPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYS
PVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTP
PASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHL
GNNRTVSIDNLKPTSHQ

3D structure

• PDB: 7adv HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.
• Chain: A
• Resolution: 2.65 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I112 L113 R114 P115 E207 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 N348 R350 T351	I104 L105 R106 P107 E199 S201 T202 Q207 S208 G210 K211 R214 R221 S250 P251 N340 R342 T343
BS02	dna	A	E221 R222 S225 K228 K262	E213 R214 S217 K220 K254
BS03	MG	A	D128 D185	D120 D177
BS04	MG	A	D128 E221	D120 E213
BS05	ZN	A	H62 H66 C96 C99	H54 H58 C88 C91
BS06	R7N	A	D128 D185 Q186 Y212 P214 Q215 E221 R329 R362	D120 D177 Q178 Y204 P206 Q207 E213 R321 R354

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:7adv, PDBe:7adv, PDBj:7adv
• PDBsum: 7adv
• PubMed: 33686850
• UniProt: P14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)