Structure of PDB 7ad6 Chain A

Receptor sequence

>7ad6A (length=971) Species: 9606 (Homo sapiens)

EEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCV
VASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRR
KQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSV
VRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPSSKCVRQKVEGS
SSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSG
VTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAV
LSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIE
KQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNK
YVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENS
LYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAIS
AYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPN
TGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTI
NAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVL
LNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEADYK
RIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLF
TDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHR
PDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQ
TACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITF
IKKVTCTNAELVKGRQYLIMGKEALQIFRYIYPLDSLTWIEYWPRDTTCS
SCQAFLANLDEFAEDIFLNGC

3D structure

• PDB: 7ad6 The allosteric modulation of Complement C5 by knob domain peptides.
• Chain: A
• Resolution: 2.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CYS	A	Y700 C704	Y17 C21

Gene Ontology

Molecular Function

• GO:0004866 endopeptidase inhibitor activity

Biological Process

• GO:0006954 inflammatory response
• GO:0006956 complement activation

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:7ad6, PDBe:7ad6, PDBj:7ad6
• PDBsum: 7ad6
• PubMed: 33570492
• UniProt: P01031|CO5_HUMAN Complement C5 (Gene Name=C5)