Structure of PDB 7aaz Chain A

Receptor sequence
>7aazA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
QNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKL
DNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPF
MKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRD
LAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLA
DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPE
DCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPD
3D structure
PDB7aaz A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.
ChainA
Resolution1.855 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 R727 N728 D741
Catalytic site (residue number reindexed from 1) D150 R154 N155 D168
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R6K A A617 F634 E637 M641 L671 F673 M674 M730 D741 F742 G743 S745 Y753 A44 F61 E64 M68 L98 F100 M101 M157 D168 F169 G170 S172 Y180 BindingDB: IC50=<10nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7aaz, PDBe:7aaz, PDBj:7aaz
PDBsum7aaz
PubMed33119085
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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