Structure of PDB 7a8u Chain A

Receptor sequence
>7a8uA (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]
SAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED
FRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA
GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQ
ILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELD
YHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFA
KRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGER
QSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD
QSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALE
DQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRV
GWELLLTTIARTINEVETQILTRD
3D structure
PDB7a8u Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.
ChainA
Resolution3.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R398 K405 D456 R457 Q460 A463 E467 R126 K133 D184 R185 Q188 A191 E195
External links
PDB RCSB:7a8u, PDBe:7a8u, PDBj:7a8u
PDBsum7a8u
PubMed34049882
UniProtP35609|ACTN2_HUMAN Alpha-actinin-2 (Gene Name=ACTN2)

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