Structure of PDB 7a7a Chain A

Receptor sequence
>7a7aA (length=657) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTT
SQPWWPADYGHYGPLFIRMARHAAGTYRIHDGRGGAGGGMQRFAPLNSWP
DNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFG
RVDQWEPDEVYDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGA
GPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKW
DNSFLEILYGYEWELTKSWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDL
SLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVP
KQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAASS
FRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAA
PGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVE
SFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLR
VLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKD
GSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVM
NLDRFDV
3D structure
PDB7a7a Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
ChainA
Resolution3.08 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.11.1.21: catalase peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A P100 R104 R107 F252 I266 G269 H270 K274 T275 H276 L378 P64 R68 R71 F174 I188 G191 H192 K196 T197 H198 L296
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0016677 oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0070402 NADPH binding
GO:0070404 NADH binding
Biological Process
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0045739 positive regulation of DNA repair
GO:0046677 response to antibiotic
GO:0070301 cellular response to hydrogen peroxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a7a, PDBe:7a7a, PDBj:7a7a
PDBsum7a7a
PubMed33444527
UniProtP9WIE5|KATG_MYCTU Catalase-peroxidase (Gene Name=katG)

[Back to BioLiP]