Structure of PDB 7a5x Chain A

Receptor sequence
>7a5xA (length=472) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
GAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLH
SSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMV
LVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGE
KGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIY
FTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVG
PGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAG
EAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDL
QVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGP
KRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEH
TEKGQNAYTLSFRKFNWDFLSK
3D structure
PDB7a5x Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases*.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R7H A R332 D357 D402 F428 Y575 Q587 R626 R648 Y680 R706 Y737 R28 D53 D98 F124 Y271 Q283 R322 R344 Y376 R402 Y433
BS02 CA A D360 N383 L384 S397 D56 N79 L80 S93
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:7a5x, PDBe:7a5x, PDBj:7a5x
PDBsum7a5x
PubMed33150981
UniProtP62575|NANA_STREE Sialidase A (Gene Name=nanA)

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