Structure of PDB 7a4v Chain A

Receptor sequence
>7a4vA (length=521) Species: 10029 (Cricetulus griseus) [Search protein sequence]
GTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIG
DAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPY
IQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFN
DAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGG
GAFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKD
VRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKF
EELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKE
FFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIE
TVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTFTIKVYEGERPLTKDNH
LLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITIT
NDQNRLTPEEIERMVNDAEKF
3D structure
PDB7a4v Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G36 T38 Y39 G226 G227 G255 E293 K296 R297 S300 G363 G364 R367 G9 T11 Y12 G199 G200 G228 E266 K269 R270 S273 G336 G337 R340
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:7a4v, PDBe:7a4v, PDBj:7a4v
PDBsum7a4v
PubMed33295873
UniProtG3I8R9|BIP_CRIGR Endoplasmic reticulum chaperone BiP (Gene Name=HSPA5)

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