Structure of PDB 7a4m Chain A

Receptor sequence
>7a4mA (length=172) Species: 10090 (Mus musculus) [Search protein sequence]
PSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKY
FLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECAL
HLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLSEQVKSIKELGDHVTN
LRKMGAPEAGMAEYLFDKHTLG
3D structure
PDB7a4m Single-particle cryo-EM at atomic resolution.
ChainA
Resolution1.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E27 E62 H65 E23 E58 H61
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140315 iron ion sequestering activity
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006955 immune response
GO:0008285 negative regulation of cell population proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0110076 negative regulation of ferroptosis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0044754 autolysosome
GO:0071682 endocytic vesicle lumen

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Cellular Component
External links
PDB RCSB:7a4m, PDBe:7a4m, PDBj:7a4m
PDBsum7a4m
PubMed33087931
UniProtP09528|FRIH_MOUSE Ferritin heavy chain (Gene Name=Fth1)

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