Structure of PDB 7a3x Chain A

Receptor sequence
>7a3xA (length=360) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence]
DRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAAVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMS
KQSEEGVTFHMLSPERSIEIQHLLGSDIVMAFDESTPYPATPSRAASSME
RSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGF
DGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVE
RGIDMFDSVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVC
QKWSRACIHALIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQF
AQDFRARYFA
3D structure
PDB7a3x Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A C318 C320 C323 H349 C295 C297 C300 H326
BS02 QXB A T47 A48 A49 L54 V59 M93 T38 A39 A40 L44 V49 M83
BS03 QXB A V45 L54 I351 V36 L44 I328
BS04 QXB A Q292 P299 Q269 P276
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7a3x, PDBe:7a3x, PDBj:7a3x
PDBsum7a3x
PubMed34081441
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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