Structure of PDB 7a3k Chain A

Receptor sequence
>7a3kA (length=821) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKMAKAPHDFMFVKRNDPDGPHSDRIYYL
AMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQGIASYDYHQGSG
TFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPD
WIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEE
FDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRA
DSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVE
YIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLI
ESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGF
RHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHG
SNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCC
ISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGP
LPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQL
VNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIE
IDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAI
AGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLL
LLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHY
ELHLLHYLQENLGSRIAALKV
3D structure
PDB7a3k Discovery and Development of 4-Oxo-beta-Lactams as Novel Inhibitors of Dipeptidyl Peptidases 8 and 9
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y593 S679 Y680 D757 H789
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMO A Y669 S755 Y787 Y791 Y593 S679 Y711 Y715
BS02 QX8 A R688 W754 H865 S866 R612 W678 H789 S790
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a3k, PDBe:7a3k, PDBj:7a3k
PDBsum7a3k
PubMed
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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