Structure of PDB 7a1w Chain A

Receptor sequence
>7a1wA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKH
3D structure
PDB7a1w KRAS G12C fragment screening renders new binding pockets.
ChainA
Resolution1.76 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146
BS02 QWK A C12 P34 T35 A59 E62 E63 Y64 M67 C12 P34 T35 A59 E62 E63 Y64 M67
BS03 QWK A C118 Q150 C118 Q150
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a1w, PDBe:7a1w, PDBj:7a1w
PDBsum7a1w
PubMed34558391
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]