Structure of PDB 7a0v Chain A

Receptor sequence
>7a0vA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
SKPKKIRVCVGTWNVNGGKQFRSINQTLTDWLLDAPKLAGIQEFQDKRSK
PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLAS
EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHT
TSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGD
FNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF
APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNYT
WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEV
3D structure
PDB7a0v A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N543 E591 N16 E61
Gene Ontology
Molecular Function
GO:0016791 phosphatase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7a0v, PDBe:7a0v, PDBj:7a0v
PDBsum7a0v
PubMed33349335
UniProtO43426|SYNJ1_HUMAN Synaptojanin-1 (Gene Name=SYNJ1)

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