Structure of PDB 6zyi Chain A

Receptor sequence
>6zyiA (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGD
AAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKV
QVSYKGDTKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDS
QRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTERNVLIFDLGGGTFD
VSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQN
KRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELC
SDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNG
RDLNKSINPDEAVAYGAAVQAAILM
3D structure
PDB6zyi Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
ChainA
Resolution1.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G12 T14 Y15 G201 G202 E268 K271 R272 S275 G339 R342 G9 T11 Y12 G195 G196 E262 K265 R266 S269 G333 R336
BS02 CA A H227 D232 H221 D226
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:6zyi, PDBe:6zyi, PDBj:6zyi
PDBsum6zyi
PubMed33295873
UniProtP0DMV8|HS71A_HUMAN Heat shock 70 kDa protein 1A (Gene Name=HSPA1A)

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