Structure of PDB 6zyh Chain A

Receptor sequence
>6zyhA (length=379) Species: 10029 (Cricetulus griseus) [Search protein sequence]
GTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIG
DAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPY
IQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFN
DAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGG
GTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKD
VRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKF
EELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKE
FFNGKEPSRGINPDEAVAYGAAVQAGVLS
3D structure
PDB6zyh Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G36 T38 Y39 G226 G227 E293 K296 R297 S300 G364 R367 G9 T11 Y12 G199 G200 E266 K269 R270 S273 G337 R340
BS02 CA A H252 D257 H225 D230
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:6zyh, PDBe:6zyh, PDBj:6zyh
PDBsum6zyh
PubMed33295873
UniProtG3I8R9|BIP_CRIGR Endoplasmic reticulum chaperone BiP (Gene Name=HSPA5)

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