Structure of PDB 6zxr Chain A

Receptor sequence
>6zxrA (length=212) Species: 9031 (Gallus gallus) [Search protein sequence]
MNIFRLTGDLSHLAAIIILLLKIWKSRSCAGISGKSQLLFALVFTTRYLD
LFTSFISLYNTSMKLIYIACSYATVYLIYMKFKATYDGNHDTFRVEFLIV
PVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTH
YLFFLGLYRALYLVNWIWRYYFEGFFDLIAVVAGVVQTVLYCDFFYLYVT
KVLKGKKLSLPA
3D structure
PDB6zxr A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R5 D9 R47 Y48 I56 E117 W120 Y162 W166 R169 R5 D9 R47 Y48 I56 E117 W120 Y162 W166 R169
Gene Ontology
Molecular Function
GO:0005046 KDEL sequence binding
GO:0046923 ER retention sequence binding
Biological Process
GO:0006621 protein retention in ER lumen
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0035437 maintenance of protein localization in endoplasmic reticulum
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016020 membrane
GO:0030663 COPI-coated vesicle membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zxr, PDBe:6zxr, PDBj:6zxr
PDBsum6zxr
PubMed34137369
UniProtQ5ZKX9|ERD22_CHICK ER lumen protein-retaining receptor 2 (Gene Name=KDELR2)

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