Structure of PDB 6zww Chain A

Receptor sequence

>6zwwA (length=744) Species: 562 (Escherichia coli)

TEQQKLTFTALQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMA
KEIDQAAGKVLLREAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGE
TGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPG
GCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHE
RSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG
RTYPVEVRYRPIRDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADA
LNKLNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPG
IKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICI
RLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDK
RNIQDGVRLLEELGAITTDEQASAYKLTPLGRQLSQLPVDPRLARMVLEA
QKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFV
NLWNYLGEQQKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELG
IPVNSEPAEYREIHIALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSG
LFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHW
ERAQGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHA

3D structure

• PDB: 6zww Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
• Chain: A
• Resolution: 3.16 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P130 R132 R159 T174 G176 I177 A180 G299 E300 A325 N349 V350 S354 R370 L383 Q495 P497 R533 Q600 F655 P656 F661 V674 T676 W680 R682	P129 R131 R158 T173 G175 I176 A179 G290 E291 A316 N340 V341 S345 R361 L374 Q486 P488 R524 Q591 F646 P647 F652 V665 T667 W671 R673

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6zww, PDBe:6zww, PDBj:6zww
• PDBsum: 6zww
• PubMed: 34290142
• UniProt: P43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)