Structure of PDB 6zvl Chain A

Receptor sequence
>6zvlA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNREN
CDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSS
DVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGG
TGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRCAPTEAIRRG
IRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDEAQL
TVDNVHLPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHW
TDVQVKGTSLPRALHCWDRSLHTPLKGCPVHLVDSCPWPHCNPSCPTG
3D structure
PDB6zvl 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QR2 A G127 W128 S232 A233 F268 I291 F319 F320 G42 W43 S147 A148 F183 I197 F225 F226 MOAD: ic50=18nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6zvl, PDBe:6zvl, PDBj:6zvl
PDBsum6zvl
PubMed33124429
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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