Structure of PDB 6zu8 Chain A

Receptor sequence
>6zu8A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSF
LLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAP
VSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVRMITSHCFPETQFIA
VTAYQNEEITALKIKYNPFAKAFLHHHHH
3D structure
PDB6zu8 Crystal structure of human Brachyury G177D variant in complex with Afatinib
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E167 C186 E127 C142
BS02 0WN A C122 V123 H171 I182 C82 V83 H131 I138
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zu8, PDBe:6zu8, PDBj:6zu8
PDBsum6zu8
PubMed
UniProtO15178|TBXT_HUMAN T-box transcription factor T (Gene Name=TBXT)

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