Structure of PDB 6zt2 Chain A

Receptor sequence

>6zt2A (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]

TRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELP
GAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSA
QGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPY
VATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRA
SIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYG
CK

3D structure

PDB

6zt2 17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with 3-chloro-2,6-difluorophenol

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.62: 17beta-estradiol 17-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	BGC	A	W188 T189 P190 E193	W184 T185 P186 E189
BS02	NAD	A	G16 R19 G20 I21 D40 K41 D62 V63 N89 L113 S141 Y154 K158 P184 G185 N186 I187 T189 L191	G12 R15 G16 I17 D36 K37 D58 V59 N85 L109 S137 Y150 K154 P180 G181 N182 I183 T185 L187
BS03	QPK	A	H93 S141 Y154 N186 W192	H89 S137 Y150 N182 W188

Gene Ontology

	Molecular Function
GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity

	Biological Process
GO:0006706	steroid catabolic process
GO:0008202	steroid metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6zt2, PDBe:6zt2, PDBj:6zt2
PDBsum	6zt2
PubMed
UniProt	Q9BPX1\|DHB14_HUMAN 17-beta-hydroxysteroid dehydrogenase 14 (Gene Name=HSD17B14)

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