Structure of PDB 6zsi Chain A

Receptor sequence
>6zsiA (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
TYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELD
GKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWI
RNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAK
ANINVENAFFTLARDIKAKMD
3D structure
PDB6zsi The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
ChainA
Resolution1.914 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A S17 G18 V19 G20 K21 T22 C23 F33 N34 S35 F37 S39 T40 G66 N121 K122 D124 S151 K153 S14 G15 V16 G17 K18 T19 C20 F30 N31 S32 F34 S36 T37 G63 N118 K119 D121 S148 K150 MOAD: Kd=0.29uM
BS02 MG A T22 T40 T19 T37
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6zsi, PDBe:6zsi, PDBj:6zsi
PDBsum6zsi
PubMed32826901
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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