Structure of PDB 6zpl Chain A

Receptor sequence
>6zplA (length=518) Species: 9606 (Homo sapiens) [Search protein sequence]
NQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPAF
FMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAF
YYFFSSMTHVLPWAYCNNPWNTHDCAGVLDHSLQRTSPSEEYWRLYVLKL
SDDIGNFGEVRLPLLGCLGVAWLVVFLCLIRGVVYFTATFPYVVLTILFV
RGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQAFYSLGCAWGGLITM
ASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRV
ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT
AIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAA
SFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPA
IIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRL
ARTDGDTLLQRLKNATKP
3D structure
PDB6zpl Structural insights into the inhibition of glycine reuptake.
ChainA
Resolution3.945 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QET A Y116 A117 V118 G119 N122 S371 W376 G378 L379 M382 N403 T472 Y12 A13 V14 G15 N18 S239 W244 G246 L247 M250 N271 T340
BS02 NA A G115 Y116 V118 G119 G11 Y12 V14 G15
BS03 CL A Y142 Q367 S371 S407 Y38 Q235 S239 S275
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6zpl, PDBe:6zpl, PDBj:6zpl
PDBsum6zpl
PubMed33658720
UniProtP48067|SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (Gene Name=SLC6A9)

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