Structure of PDB 6zor Chain A

Receptor sequence
>6zorA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDAHRLHAP
3D structure
PDB6zor Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
ChainA
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QNH A M343 L346 T347 A350 D351 E353 L384 L387 L391 R394 F404 G521 L525 V533 P535 M41 L44 T45 A48 D49 E51 L82 L85 L89 R92 F102 G211 L215 V219 P221
External links
PDB RCSB:6zor, PDBe:6zor, PDBj:6zor
PDBsum6zor
PubMed32910656
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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