Structure of PDB 6znq Chain A

Receptor sequence

>6znqA (length=748) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIKAALSKRG
IDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNR
ALYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAG
HIVITNPDMLHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANV
IRRLKRICRFYGSDPVFICTSATIANPKELGEQLTGKPMRLVDDNGAPSG
RKHFVFYNPPIVNKPLNIRRSATAEVNELAKEFLKNKVQTIVFARSRVRV
EIILSHIQELVKKEIGTKSIRGYRGGYLPKERREIERGLREGDILGVVST
NALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGESLIIMVANST
PIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEEF
GAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIV
DQSDIANVRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYV
RKVDVEYYTDANLAVQLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKI
KMTTFENIGSGPIHLPEEELHTSAAWLEIKTADEDIGEKTLEQLLLGISN
VLQHIVPVYIMCDRNDVHVVSQIKAAHTGLPTIFLYDHYPGGIGLAEEVF
KRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKERILQLLDQMS

3D structure

• PDB: 6znq A skipping rope translocation mechanism in a widespread family of DNA repair helicases.
• Chain: A
• Resolution: 3.34 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	T108 K109 Y135 G137 R144 R148 N157 D159 M160 S163 A164 H168 K171 S297 R298 R325 G326 R333 T351 N352 A353 F483 R491 S494 Q495 N666	T107 K108 Y134 G136 R143 R147 N156 D158 M159 S162 A163 H167 K170 S296 R297 R324 G325 R332 T350 N351 A352 F482 R490 S493 Q494 N665
BS02	ZN	A	C718 C720 C724 C727	C717 C719 C723 C726
BS03	ANP	A	G51 I52 Y56 T78 A79 G81 K82 T83 G357	G50 I51 Y55 T77 A78 G80 K81 T82 G356

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0043138 3'-5' DNA helicase activity

Biological Process

• GO:0006289 nucleotide-excision repair
• GO:0032508 DNA duplex unwinding
• GO:0036297 interstrand cross-link repair

External links

• PDB: RCSB:6znq, PDBe:6znq, PDBj:6znq
• PDBsum: 6znq
• PubMed: 33300032
• UniProt: P50830|YPRA_BACSU Uncharacterized ATP-dependent helicase YprA (Gene Name=yprA)