Structure of PDB 6znc Chain A

Receptor sequence
>6zncA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCLAPPQHLIRVE
GNLRVEYLDDRNTFRHSVVVPYEPPEVSDCTTIHYNYMCNSSCMGGMNRR
PILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKG
3D structure
PDB6znc Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna A K120 S121 Q165 S166 R248 K27 S28 Q72 S73 R149
BS02 ZN A C176 H179 C238 C242 C83 H86 C139 C143
BS03 QNN A S116 T123 C124 S23 T30 C31
BS04 QNN A K120 S121 A276 C277 K27 S28 A177 C178
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6znc, PDBe:6znc, PDBj:6znc
PDBsum6znc
PubMed34862374
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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