Structure of PDB 6zjf Chain A

Receptor sequence
>6zjfA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
TENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKK
RRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGG
EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILL
SSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTAT
DMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLA
TDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSS
3D structure
PDB6zjf A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D158 K160 Q162 N163 D179 T198
Catalytic site (residue number reindexed from 1) D142 K144 Q146 N147 D163 T182
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QM2 A L39 A60 K62 E111 Y112 A113 G116 L165 D179 L23 A44 K46 E95 Y96 A97 G100 L149 D163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6zjf, PDBe:6zjf, PDBj:6zjf
PDBsum6zjf
PubMed33215924
UniProtO94768|ST17B_HUMAN Serine/threonine-protein kinase 17B (Gene Name=STK17B)

[Back to BioLiP]