Structure of PDB 6zis Chain A

Receptor sequence

>6zisA (length=569) Species: 9606,1327989 [Search protein sequence]

SAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFP
QVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVR
YNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALM
FNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDL
IKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLP
TFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKP
LGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVI
NAASGRQTVDEALKDAQTNAAAEFTTACQEANYGALLRELCLTQFQVDME
AVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGR
YFRSCPISIQLGVTRNKIMTAQYECYQKIMQDPIQQGVYCQRTWDGWLCW
NDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASQRTWTDYT
QCNVNTHEKVKTALNLFYL

3D structure

PDB

6zis Structure-Based Drug Discovery ofN-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.

Chain

Resolution

1.73 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	D16 K17 E113 W232	D16 K17 E113 W232
BS02	GLC	A	W64 D67 R68 E155 P156 Y157 W342	W64 D67 R68 E155 P156 Y157 W342
BS03	3N6	A	A1070 D1071 W1074 W1084 R2038 I2041 M2042 D2070 G2071 W2072 F2092 D2094 W2121 T2122 Y2124	A421 D422 W425 W435 R465 I468 M469 D495 G496 W497 F517 D519 W546 T547 Y549

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6zis, PDBe:6zis, PDBj:6zis
PDBsum	6zis
PubMed	32558564
UniProt	A0A4P1LXE0; O60894\|RAMP1_HUMAN Receptor activity-modifying protein 1 (Gene Name=RAMP1); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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