Structure of PDB 6zci Chain A

Receptor sequence
>6zciA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB6zci BET bromodomain inhibitors regulate keratinocyte plasticity.
ChainA
Resolution1.976 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QFN A W81 P82 F83 L92 Y139 N140 D145 I146 W40 P41 F42 L51 Y98 N99 D104 I105 BindingDB: IC50=17nM
External links
PDB RCSB:6zci, PDBe:6zci, PDBj:6zci
PDBsum6zci
PubMed33462494
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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