Structure of PDB 6zc8 Chain A

Receptor sequence
>6zc8A (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
MSLNIITVTLNMEKYNFLGISIVGQSNERGGIYIGSIMKGGAVAADGRIE
PGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKS
3D structure
PDB6zc8 Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
ChainA
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEK A F259 L260 G261 I262 L319 R320 V323 H324 F17 L18 G19 I20 L75 R76 V79 H80
Gene Ontology
Biological Process
GO:0016055 Wnt signaling pathway

View graph for
Biological Process
External links
PDB RCSB:6zc8, PDBe:6zc8, PDBj:6zc8
PDBsum6zc8
PubMed
UniProtQ92997|DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (Gene Name=DVL3)

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