Structure of PDB 6zc0 Chain A

Receptor sequence
>6zc0A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
VYLDRKLLTLEDKELGSFGTVKKGYYQMKKVVKTVAVKILKLKDELLAEA
NVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNI
IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA
DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK
PYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAA
VELRLRNYYYDVVNHHH
3D structure
PDB6zc0 SYK Kinase domain in complex with azabenzimidazole inhibitor 2b
ChainA
Resolution1.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512
Catalytic site (residue number reindexed from 1) D123 A125 R127 N128 D141
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QDZ A L377 V385 A400 K402 M448 E449 M450 A451 E452 G454 P455 L501 D512 L15 V21 A36 K38 M77 E78 M79 A80 E81 G83 P84 L130 D141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6zc0, PDBe:6zc0, PDBj:6zc0
PDBsum6zc0
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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