Structure of PDB 6zbo Chain A

Receptor sequence
>6zboA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTG
DKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACY
PGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQF
ADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKY
LTGE
3D structure
PDB6zbo Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H313 D315 H374 H110 D112 H171
BS02 QEQ A M299 Y303 Y310 H313 D315 V376 R383 M96 Y100 Y107 H110 D112 V173 R180
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6zbo, PDBe:6zbo, PDBj:6zbo
PDBsum6zbo
PubMed33792169
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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