Structure of PDB 6zbn Chain A

Receptor sequence
>6zbnA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
PALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDGDKITWI
EGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTG
YVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPK
FDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTG
3D structure
PDB6zbn Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
ChainA
Resolution2.01 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEE A Y303 Y310 H313 D315 R322 V376 R383 W389 Y94 Y101 H104 D106 R113 V167 R174 W180
BS02 MN A H313 D315 H374 H104 D106 H165
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6zbn, PDBe:6zbn, PDBj:6zbn
PDBsum6zbn
PubMed33792169
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

[Back to BioLiP]