Structure of PDB 6z8a Chain A

Receptor sequence

>6z8aA (length=677) Species: 208964 (Pseudomonas aeruginosa PAO1)

VFALGNNLGSTDGYLATHSQIATKTSKPLLETSQTVSVITREQIDDTASK
TVQQAMRYTPGIFTGQVGASNRYDYVVMRGFADNSVDNIYLDGLKAMGDS
GTFSSMQVDPYFLERIDVLKGPSSVLYGRSLPGGLVALTSKKPLYEDYRQ
ITGSIGNMGQKEMGFDFSGPLDEEKRIAYRLIGLGKGSDTQFDHVKEERY
AIAPTLAIDFSDDTTLTLQGYLQHDPNGGYHGGVPADGTLSHHNGRHISR
EFFDGEPSKDDFDRTQRMFGYQLEHRIDDVWSARQNFRYLDSDVDLSQVY
AYGWSASEPNKLNRYFSGAREHLQAYIVDNMLQAEFATGAARHTLLTGLD
YQRRRTVVDWRSGSASALDAFNPVYGDDAISYFPDDNHTRRLEQTGVYLQ
DLIDIDQWRFSLGLRQDWVSVTDKNRSTGSKADDDWEKFTGRIGALYLFD
NGLAPYVSYSESFNPNAYSDASGTPLAPTEGKQWELGLKFQAPGSNSFYT
ASLFHITQENVASKEPQDNFYTSVGEVRSQGLELEAHTQLSDNLKLLGSY
TYTDITYTKSLDGNQGHTPNQAPKHMASLWADYAFDAGPLSGLSIGGGAR
YVGETWADKENTLRVPDYTLVDARIGYDLGKLGLKGLDVSLNANNLLDKD
YVASCYSLDFCYFGEKRNVTATVNYQF

3D structure

• PDB: 6z8a Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa : Exclusive Involvement of the FoxA Outer Membrane Transporter.
• Chain: A
• Resolution: 2.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6L0	A	Y218 T245 F246 H374 G375 Y443 Y799 Y805	Y75 T102 F103 H231 G232 Y300 Y656 Y662

Gene Ontology

Molecular Function

• GO:0015343 siderophore-iron transmembrane transporter activity
• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0007166 cell surface receptor signaling pathway
• GO:0015891 siderophore transport
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane
• GO:0019867 outer membrane

External links

• PDB: RCSB:6z8a, PDBe:6z8a, PDBj:6z8a
• PDBsum: 6z8a
• PubMed: 32902248
• UniProt: Q9I116