Structure of PDB 6z6r Chain A

Receptor sequence

>6z6rA (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]

KPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARY
GKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDR
QQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEE
VLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYF
HLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPK
ETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFT
LWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPH
TGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQ
DASSFRLIFIVDVWHPELTPQQRRSLPAI

3D structure

PDB

6z6r Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase.

Chain

Resolution

2.13 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.14.11.16: peptide-aspartate beta-dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	E390 R393 F432 L433 G434 L466 H493 F496 R526 H530 Y565 E617 Q632 K666 G681 P682 R686 R688	E61 R64 F103 L104 G105 L137 H164 F167 R197 H201 Y236 E288 Q303 K337 G352 P353 R357 R359
BS02	MN	A	H679 H725	H350 H396
BS03	UQK	A	W625 S668 M670 R688 H690 H725 V727 R735 I739	W296 S339 M341 R359 H361 H396 V398 R406 I410

Gene Ontology

	Molecular Function
GO:0062101	peptidyl-aspartic acid 3-dioxygenase activity

	Biological Process
GO:0018193	peptidyl-amino acid modification
GO:0042264	peptidyl-aspartic acid hydroxylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6z6r, PDBe:6z6r, PDBj:6z6r
PDBsum	6z6r
PubMed	34163896
UniProt	Q12797\|ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (Gene Name=ASPH)

[Back to BioLiP]