Structure of PDB 6z6h Chain A

Receptor sequence
>6z6hA (length=651) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
RQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRR
IYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEH
LEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVV
EGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRI
MILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGE
GKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDA
ADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALS
VAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSG
PINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTP
NISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSLDFIKWGLDR
KYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIG
IGDSYSGIVHLLGHRDTRAVTKTVINFLGDKQLKPLVPLVDETLSEWYFK
NSLIFSNNSHQCWKKPRKKFGRVLRCDTDGLNNIIEERFEEATDFILDSF
E
3D structure
PDB6z6h Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies.
ChainA
Resolution8.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D245 G376 D206 G337
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006355 regulation of DNA-templated transcription
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0040029 epigenetic regulation of gene expression
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0070823 HDA1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z6h, PDBe:6z6h, PDBj:6z6h
PDBsum6z6h
PubMed33523989
UniProtP53973|HDA1_YEAST Histone deacetylase HDA1 (Gene Name=HDA1)

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