Structure of PDB 6z5b Chain A

Receptor sequence
>6z5bA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
QKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGP
DLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGS
YPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTK
LSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYT
LNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQ
FDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMK
QIKRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6z5b Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003128
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q7Z A I490 E492 A509 K511 E535 S539 F605 G608 G609 L656 I686 D687 I22 E24 A41 K43 E67 S71 F137 G140 G141 L188 I218 D219
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z5b, PDBe:6z5b, PDBj:6z5b
PDBsum6z5b
PubMed
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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