Structure of PDB 6z5a Chain A

Receptor sequence
>6z5aA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTP
VAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFI
GLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEF
GGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLL
KKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMD
EDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMT
FKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6z5a Crystal structure of haspin (GSG2) in complex with macrocycle ODS2002941
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C467 H477 H563 C10 H20 H106
BS02 Q8B A I490 F495 V498 A509 K511 I532 I536 S539 F605 G608 G609 L656 I686 D687 I33 F38 V41 A52 K54 I75 I79 S82 F148 G151 G152 L199 I229 D230
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z5a, PDBe:6z5a, PDBj:6z5a
PDBsum6z5a
PubMed
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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