Structure of PDB 6z57 Chain A

Receptor sequence
>6z57A (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPD
LVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSY
PPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKL
SSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTL
NGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQF
DIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQ
IKRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6z57 Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q8W A I490 E492 A509 K511 F605 E606 F607 G609 L656 I686 D687 I21 E23 A40 K42 F136 E137 F138 G140 L187 I217 D218
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z57, PDBe:6z57, PDBj:6z57
PDBsum6z57
PubMed
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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