Structure of PDB 6z45 Chain A

Receptor sequence
>6z45A (length=314) Species: 9606 (Homo sapiens) [Search protein sequence]
YDDNECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQRVALKKVLMEN
EKEGFPITALREIKILQLLKHENVVNLIEICRTKCKGSIYLVFDFCEHDL
AGLLSNVLVKFTLSEIKRVMQMLLNGLFYIHRNKILHRDMKAANVLITRD
GVLKLADFGLARAFSLNPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWG
AGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEK
LELVKGQKRKVKDRLAAYVRDPYALDLIDKLLVLDPAQRIDSEDALEHDF
FWSDPMPSDLKGML
3D structure
PDB6z45 Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
ChainA
Resolution3.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 N154 D167 T191
Catalytic site (residue number reindexed from 1) D139 K141 N144 D157 T177
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q6E A I25 A46 F103 F105 C106 E107 D109 L156 I21 A42 F93 F95 C96 E97 D99 L146 BindingDB: IC50=<4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6z45, PDBe:6z45, PDBj:6z45
PDBsum6z45
PubMed33306391
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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