Structure of PDB 6z2a Chain A

Receptor sequence
>6z2aA (length=283) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
DSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYR
LTQGVIPPDPNAQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQG
RVRADTGAVIYECNSACSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRS
LRFAPAGTFITCYLGEVITSAEAAKRDKNDDGITYLFDLDMFDDASEYTV
DAQNYGDVSRFFNHSCSPNIAIYSAVRNHGARTIYDLAFFAIKDIQPLEE
LTFDYAGAKDFSPVQLRRQCKCGSANCRGWLFG
3D structure
PDB6z2a SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
ChainA
Resolution2.456 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.366: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C260 C262 C268 C276 C66 C68 C74 C82
BS02 ZN A C260 C278 C307 C311 C66 C84 C113 C117
BS03 ZN A C268 C307 C313 C317 C74 C113 C119 C123
BS04 ZN A C412 C477 C479 C484 C216 C270 C272 C277
BS05 SAH A K338 W340 Y381 R406 N409 H410 Y451 R475 F489 K144 W146 Y185 R210 N213 H214 Y255 R268 F282
BS06 MG A D386 G453 D190 G257
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0042054 histone methyltransferase activity
GO:0046974 histone H3K9 methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6z2a, PDBe:6z2a, PDBj:6z2a
PDBsum6z2a
PubMed34524082
UniProtO60016|CLR4_SCHPO Histone-lysine N-methyltransferase, H3 lysine-9 specific (Gene Name=clr4)

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