Structure of PDB 6z15 Chain A

Receptor sequence
>6z15A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHRGAVSQRLYILLPLDCGV
PDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCV
LEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNN
CRLIAYQEPSSFSLSQEVLRHLRQEEKEE
3D structure
PDB6z15 Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BA A S162 Y167 R238 Y240 S9 Y14 R80 Y82 BindingDB: EC50=200nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6z15, PDBe:6z15, PDBj:6z15
PDBsum6z15
PubMed33616279
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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