Structure of PDB 6yz4 Chain A

Receptor sequence
>6yz4A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
KQTGYLTIGGQRYQAEINDLENLGEMGGQVWKMRFRKTGHVIAVKQMRRS
GNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAE
KLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDER
GQIKLCDFGISGRLGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVE
LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKD
HRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP
3D structure
PDB6yz4 Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D259 K261 N264 D277 C296
Catalytic site (residue number reindexed from 1) D139 K141 N144 D157 C166
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1E8 A Y121 L122 I133 W151 M153 G200 T201 F202 F209 Y5 L6 I17 W31 M33 G80 T81 F82 F89
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6yz4, PDBe:6yz4, PDBj:6yz4
PDBsum6yz4
PubMed32783966
UniProtO14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (Gene Name=MAP2K7)

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