Structure of PDB 6yyg Chain A

Receptor sequence
>6yygA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVILESIFLKRSQQSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGS
IDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVV
YDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCC
SQTAKNAMGCQILE
3D structure
PDB6yyg Optimising crystallographic systems for structure-guided drug discovery
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q1B A K12 S14 Q15 L37 Y39 S55 I56 Y106 L111 K11 S13 Q14 L32 Y34 S50 I51 Y101 L106
BS02 ZN A H143 C154 C155 C165 H138 C149 C150 C160
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6yyg, PDBe:6yyg, PDBj:6yyg
PDBsum6yyg
PubMed
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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