Structure of PDB 6yyc Chain A

Receptor sequence
>6yycA (length=295) Species: 561007 (Mycobacteroides abscessus ATCC 19977) [Search protein sequence]
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKG
RILTAMSVFFFGLLTVPNHLAGPPDDPRIPEEVLGRALLVRRLDMLPVEC
VARGYLTGSGLLDYQRTGAVCGHVLPQGLGEASRLDPPLFTPATKADIGE
HDMNVDFAAVVGLVGAVRANQLRDETIKIYTRAAAHALHKGIILADTKFE
FGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDKQFVRNWLTGP
ESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGP
3D structure
PDB6yyc Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
ChainA
Resolution1.274 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q0Z A A12 S13 R17 E18 L19 L27 F29 H69 R92 L93 M95 A12 S13 R17 E18 L19 L27 F29 H69 R92 L93 M95
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yyc, PDBe:6yyc, PDBj:6yyc
PDBsum6yyc
PubMed35037462
UniProtB1MHW4|PUR7_MYCA9 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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