Structure of PDB 6yxw Chain A

Receptor sequence
>6yxwA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETC
LLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQG
VDDAFYTLVREIRKHK
3D structure
PDB6yxw RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G12 G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147 G11 G12 V13 G14 K15 S16 A17 F27 D29 N115 K116 D118 S144 A145 K146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yxw, PDBe:6yxw, PDBj:6yxw
PDBsum6yxw
PubMed34193876
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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