Structure of PDB 6yxh Chain A

Receptor sequence
>6yxhA (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
FAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFG
AVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSC
CIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYG
MLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLR
NFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRADLEDN
WETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSP
EMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYL
3D structure
PDB6yxh An automated platform for structural analysis of membrane proteins through serial crystallography.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.23: ceramidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H81 H217 H221 H81 H217 H221
BS02 CA A D19 W20 E22 N24 E33 D19 W20 E22 N24 E33
BS03 MG A E60 K114 N115 E60 K114 N115
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0009055 electron transfer activity
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040 N-acylsphingosine amidohydrolase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006954 inflammatory response
GO:0008284 positive regulation of cell population proliferation
GO:0022900 electron transport chain
GO:0042552 myelination
GO:0043067 regulation of programmed cell death
GO:0046512 sphingosine biosynthetic process
GO:0046514 ceramide catabolic process
GO:0071602 phytosphingosine biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6yxh, PDBe:6yxh, PDBj:6yxh
PDBsum6yxh
PubMed34723237
UniProtQ9NUN7|ACER3_HUMAN Alkaline ceramidase 3 (Gene Name=ACER3)

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