Structure of PDB 6yw9 Chain A

Receptor sequence
>6yw9A (length=315) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
FQGPHMFELSDVIEGKQFDREMLSAIFDVAREMEKIEKSSSQSEILKGYL
MATLFYEPSTRTRLSFESAMKRLGGEVLTTENAREASSAAKGETLEDTIR
TVEGYSDIIVMRHFESGAARKAAATANIPVINAGDGPGEHPTQALLDVYT
IQSEIGKLDGISVALVGDLANGRTVRSLAYLLAKFKDVKIYFVSPEIVKM
KDDIKDYLTSSGVEWEESSDLMEVASKCDVVYQTRIQRERFGERLDLYEA
ARGKFIVDKDLLGVMQKKAIIMHPLPRLDEITADVDADPRAAYFRQAKNG
LFIRMALLKLLLVGW
3D structure
PDB6yw9 Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase.
ChainA
Resolution1.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R187 H215 Q218 T309 P349 G375
Catalytic site (residue number reindexed from 1) R112 H140 Q143 T234 P274 G300
Enzyme Commision number 2.1.3.2: aspartate carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAL A S134 T135 R136 T137 R187 H215 R248 T249 R310 Q312 L350 S59 T60 R61 T62 R112 H140 R173 T174 R235 Q237 L275
BS02 PAL A S163 K166 S88 K91
Gene Ontology
Molecular Function
GO:0004070 aspartate carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520 amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6yw9, PDBe:6yw9, PDBj:6yw9
PDBsum6yw9
PubMed33574254
UniProtP49077|PYRB_ARATH Aspartate carbamoyltransferase, chloroplastic (Gene Name=PYRB)

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