Structure of PDB 6yw4 Chain A

Receptor sequence
>6yw4A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
KPLPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKF
TDGQDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGR
TKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRI
FPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADE
RAAAKVKYLT
3D structure
PDB6yw4 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
ChainA
Resolution1.528 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K186 P187 L188 Y197 P200 A201 K204 H205 I207 V209 V210 D211 D212 F213 K1 P2 L3 Y12 P15 A16 K19 H20 I22 V24 V25 D26 D27 F28
BS02 MN A H313 D315 H374 H118 D120 H179
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yw4, PDBe:6yw4, PDBj:6yw4
PDBsum6yw4
PubMed33319810
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

[Back to BioLiP]